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Catching Multiple Sclerosis before it Strikes
Although there is currently no cure for multiple sclerosis (MS), a breakthrough finding from a Tel Aviv University scientist and physician may lead to earlier diagnosis, more effective intervention, and perhaps even a cure for the autoimmune disease.
Anat Achiron of Tel Aviv University's Sackler Faculty of Medicine and vice-dean of research at Sheba Medical Center has uncovered a new way of detecting MS in the blood through her research at Sheba. The findings are expected to pave the way for a diagnosis of MS before symptoms can appear, allowing for earlier treatment.
"We are not yet able to treat people with MS to prevent the onset of the disease but knowledge is power," Achiron says. "Every time we meet a new patient exhibiting symptoms of MS, we must ask ourselves how long this has been going on. We can diagnose MS by brain MRI, but we've never been able to know how 'fresh' the disease is," she says.
If doctors can predict the onset of MS early enough, intervention therapies using immunomodulatory drugs or beta-interferon drugs that stave off MS symptoms, might be used.
"We theorised that if we looked at the gene expression signature of blood cells in healthy people, we could look for possible biological markers that characterize those who subsequently developed MS," says Achiron.
Examining blood samples of twenty 19-year-old Israelis who were inducted into the army as healthy soldiers, and the nine of them who later developed MS, Achiron and her team at Sheba were able to use a "high throughput analysis" using more than 12,000 gene transcripts expressions. The screening compared similarities and differences in the blood of those who developed MS and those who did not, eventually establishing biological markers.
"Those who will develop MS will show a different blood signature from those who will not," says Achiron. "When we compared the gene expression signatures, we saw a similar pattern of the same working biological processes."
These early genetic markers may now be used to test for multiple sclerosis up to nine years before healthy young adults start developing symptoms. And because MS is thought to have a genetic component and a tendency to be found in siblings, Achiron says the biomarkers can be used as a tool for brothers and sisters of patients.
Why test in advance of a cure? "The idea is that we'll know more about the genetics of MS through this new discovery, with the hope that early intervention therapies may be more effective, and help advance medicine toward a cure," Achiron says.
REHACARE.de; Source: American Friends of Tel Aviv University
- More about the American Friends of Tel Aviv University at www.aftau.org
( Source: REHACARE.de )